diff --git a/core/net/mac/framer-802154.c b/core/net/mac/framer-802154.c
index 9f97ff8a2..d934b62a4 100644
--- a/core/net/mac/framer-802154.c
+++ b/core/net/mac/framer-802154.c
@@ -130,6 +130,10 @@ create_frame(int type, int do_create)
     params.seq = packetbuf_attr(PACKETBUF_ATTR_MAC_SEQNO);
 
   } else {
+    /* Ensure that the sequence number 0 is not used as it would bypass the above check. */
+    if(mac_dsn == 0) {
+      mac_dsn++;
+    }
     params.seq = mac_dsn++;
     packetbuf_set_attr(PACKETBUF_ATTR_MAC_SEQNO, params.seq);
   }